Cyclooxygenase-2 (COX-2) Inhibition Constrains Indoleamine 2,3-Dioxygenase 1 (IDO1) Activity in Acute Myeloid Leukaemia Cells

Cyclooxygenase-2 (COX-2) Inhibition Constrains Indoleamine 2,3-Dioxygenase 1 (IDO1) Activity in Acute Myeloid Leukaemia Cells

Indoleamine 2,3-dioxygenase 1 (IDO1) metabolizes L-tryptophan to kynurenines (KYN), inducing T-cell suppression either directly or by altering antigen-presenting-cell function. Cyclooxygenase (COX)-2, the rate-limiting enzyme in the synthesis of prostaglandins, is over-expressed by several tumours....

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Bibliographic Details
Main Authors: Sergio Rutella, Raimondo De Cristofaro, Franco Locatelli, Giuseppina Bonanno, Andrea Mariotti, Maria Grazia Iachininoto, Annabella Procoli, Eugenia Rosa Nuzzolo
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Molecules
Subjects:
indoleamine 2-3-dioxygenase
immune tolerance
acute leukaemia
regulatory T cells
immunotherapy
interferon-γ
Online Access:http://www.mdpi.com/1420-3049/18/9/10132

Internet

http://www.mdpi.com/1420-3049/18/9/10132

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