Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain

Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain

Protein kinase A (PKA) plays critical roles in neuronal function that are mediated by different regulatory (R) subunits. Deficiency in either the RIβ or the RIIβ subunit results in distinct neuronal phenotypes. Although RIβ contributes to synaptic plasticity, it is the least studied isoform. Using i...

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Bibliographic Details
Main Authors: Ronit Ilouz, Varda Lev-Ram, Eric A Bushong, Travis L Stiles, Dinorah Friedmann-Morvinski, Christopher Douglas, Jeffrey L Goldberg, Mark H Ellisman, Susan S Taylor
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
protein kinases
cellular and subcellular localization
Immunohistochemical mouse brain images
correlated light and electron microscopy
High resolution large scale images
PKA regulatory subunits
Online Access:https://elifesciences.org/articles/17681

Internet

https://elifesciences.org/articles/17681

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