Paclitaxel Inhibits Synoviocyte Migration and Inflammatory Mediator Production in Rheumatoid Arthritis

Paclitaxel Inhibits Synoviocyte Migration and Inflammatory Mediator Production in Rheumatoid Arthritis

Activated fibroblast-like synoviocytes (FLSs) play a crucial role in the pathogenesis and progression of rheumatoid arthritis (RA). It is urgent to develop new drugs that can effectively inhibit the abnormal activation of RA-FLS. In our study, the RA-FLS cell line, MH7A, and mice with collagen-induc...

Full description

Bibliographic Details
Main Authors: Xiaochen Chen, Haofeng Lin, Jinyang Chen, Lisheng Wu, Junqing Zhu, Yongnong Ye, Shixian Chen, Hongyan Du, Juan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
paclitaxel
RA-FLSs
CIA
MAPK
AKT/mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.714566/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.714566/full

Similar Items