Activity and molecular targets of pioglitazone via blockade of proliferation, invasiveness and bioenergetics in human NSCLC

Activity and molecular targets of pioglitazone via blockade of proliferation, invasiveness and bioenergetics in human NSCLC

Abstract Background Pioglitazone, a synthetic peroxisome proliferator activated receptor (PPAR-γ) ligand, is known as an antidiabetic drug included in the thiazolidinediones (TZDs) class. It regulates the lipid and glucose cell metabolism and recently a role in the inhibition of numerous cancer cell...

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Bibliographic Details
Main Authors: Vincenza Ciaramella, Ferdinando Carlo Sasso, Raimondo Di Liello, Carminia Maria Della Corte, Giusi Barra, Giuseppe Viscardi, Giovanna Esposito, Francesca Sparano, Teresa Troiani, Erika Martinelli, Michele Orditura, Ferdinando De Vita, Fortunato Ciardiello, Floriana Morgillo
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glitazones
Metabolism
Lung cancer
EMT
Bioenergetics
Online Access:http://link.springer.com/article/10.1186/s13046-019-1176-1

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http://link.springer.com/article/10.1186/s13046-019-1176-1

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