Osteopetrotic induced pluripotent stem cells derived from patients with different disease-associated mutations by non-integrating reprogramming methods

Osteopetrotic induced pluripotent stem cells derived from patients with different disease-associated mutations by non-integrating reprogramming methods

Abstract Background Autosomal recessive osteopetrosis is a genetically and phenotypically heterogeneous disease, caused by defects in osteoclast formation and function. The only available treatment is allogeneic stem cell transplantation that has still high morbidity and mortality. The goal of the p...

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Bibliographic Details
Main Authors: Fatma Visal Okur, İnci Cevher, Cansu Özdemir, Çetin Kocaefe, Duygu Uçkan Çetinkaya
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Stem Cell Research & Therapy
Subjects:
Osteopetrosis
Sendai virus
Episomal vector
Mesenchymal stromal cells
Induced pluripotent stem cells
Reprogramming
Online Access:http://link.springer.com/article/10.1186/s13287-019-1316-8

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http://link.springer.com/article/10.1186/s13287-019-1316-8

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