Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs

Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs

Osteoarthritis (OA) is a chronic disease mainly characterized by degenerative changes in cartilage, but other joint elements such as bone are also affected. To date, there are no disease-modifying OA drugs (DMOADs), owing in part to a deficiency of current models in simulating OA pathologies and eti...

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Bibliographic Details
Main Authors: Zixuan Lin, Zhong Li, Eileen N. Li, Xinyu Li, Colin J. Del Duke, He Shen, Tingjun Hao, Benjamen O'Donnell, Bruce A. Bunnell, Stuart B. Goodman, Peter G. Alexander, Rocky S. Tuan, Hang Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
iPSCs
DMOADs
tissue chip
osteoarthritis
Celecoxib
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00411/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2019.00411/full

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