Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction

Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction

Emerging evidence indicates that the enhancement of microglial autophagy inhibits the NLRP3 inflammasome mediated neuroinflammation in Alzheimer's disease (AD). Meanwhile, low density lipoprotein receptor-related protein 1 (LRP1) highly expressed in microglia is able to negatively regulate neur...

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Bibliographic Details
Main Authors: Wen-Qiao Qiu, Rong Pan, Yong Tang, Xiao-Gang Zhou, Jian-Ming Wu, Lu Yu, Betty Yuen-Kwan Law, Wei Ai, Chong-Lin Yu, Da-Lian Qin, An-Guo Wu
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Lychee seed polyphenol
Alzheimer's disease
Aβ(1-42)
NLRP3 inflammasome
LRP1/AMPK
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222030768X

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http://www.sciencedirect.com/science/article/pii/S075333222030768X

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