Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR.

Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR.

Interferon inducible protein kinase PKR is an essential component of innate immunity. It is activated by long stretches of dsRNA and provides the first line of host defense against pathogens by inhibiting translation initiation in the infected cell. Many cellular and viral transcripts contain nucleo...

Full description

Bibliographic Details
Main Authors: Subba Rao Nallagatla, Christie N Jones, Saikat Kumar B Ghosh, Suresh D Sharma, Craig E Cameron, Linda L Spremulli, Philip C Bevilacqua
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3587421?pdf=render

Internet

http://europepmc.org/articles/PMC3587421?pdf=render

Similar Items