Long Chain Omega-3 Polyunsaturated Fatty Acid Supplementation Alleviates Doxorubicin-Induced Depressive-Like Behaviors and Neurotoxicity in Rats: Involvement of Oxidative Stress and Neuroinflammation

Long Chain Omega-3 Polyunsaturated Fatty Acid Supplementation Alleviates Doxorubicin-Induced Depressive-Like Behaviors and Neurotoxicity in Rats: Involvement of Oxidative Stress and Neuroinflammation

Doxorubicin (DOX) is a chemotherapeutic agent widely used in human malignancies. Its long-term use can cause neurobiological side-effects associated with depression. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), the essential fatty acids found in fish oil, possess neuroprotecitve and antidepressa...

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Bibliographic Details
Main Authors: Yan-Qin Wu, Rui-Li Dang, Mi-Mi Tang, Hua-Lin Cai, Huan-De Li, De-Hua Liao, Xin He, Ling-Juan Cao, Ying Xue, Pei Jiang
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Nutrients
Subjects:
depression
neurotoxicity
ω-3 PUFAs
doxorubicin
oxidative stress
neuroinflammation
Online Access:http://www.mdpi.com/2072-6643/8/4/243

Internet

http://www.mdpi.com/2072-6643/8/4/243

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