CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis

CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis

Abstract Background Circular RNA hsa_circ_0008305 (circPTK2), miR-181c-5p and High mobility group box-1 (HMGB1) had a targeted regulatory relationship through bioinformatics analysis. This study explained the effects of these genes in microglia and sepsis mice. Methods Lipopolysaccharide (LPS) or Ce...

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Bibliographic Details
Main Authors: Min Li, Junwen Hu, Yucong Peng, Jingbo Li, Reng Ren
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Medicine
Subjects:
Microglia
Sepsis
CircPTK2
MiR-181c-5p
High mobility group box-1
Online Access:https://doi.org/10.1186/s10020-021-00305-3

Internet

https://doi.org/10.1186/s10020-021-00305-3

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