Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias

Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias

Although numerous factors have been found to modulate hTERT transcription, the mechanism of its repression in certain leukemias remains unknown. We show here that DEK represses hTERT transcription through its enrichment on the hTERT promoter in cells from chronic and acute myeloid leukemias, chroni...

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Bibliographic Details
Main Authors: Maroun Karam, Morgan Thenoz, Valérie Capraro, Jean-Philippe Robin, Christiane Pinatel, Agnès Lançon, Perrine Galia, David Sibon, Xavier Thomas, Sophie Ducastelle-Lepretre, Franck Nicolini, Mohamed El-Hamri, Youcef Chelghoun, Eric Wattel, Franck Mortreux
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558614800043

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http://www.sciencedirect.com/science/article/pii/S1476558614800043

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