Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis

Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis

Direct intercellular communication, mediated by gap junctions formed by the connexin transmembrane protein family, is frequently dysregulated in cancer. Connexins have been described as tumour suppressors, but emerging evidence suggests that they can also act as tumour promoters. This feature is con...

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Bibliographic Details
Main Authors: Trond Aasen, Irene Sansano, Maria Ángeles Montero, Cleofé Romagosa, Jordi Temprana-Salvador, Alexandre Martínez-Marti, Teresa Moliné, Javier Hernández-Losa, Santiago Ramón y Cajal
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
connexins
Cx43
gap junctions
lung cancer
immunohistochemistry
prognosis
nuclear
Online Access:http://www.mdpi.com/2072-6694/11/3/320

Internet

http://www.mdpi.com/2072-6694/11/3/320

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