JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS

JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS

Endotoxemia is a severe inflammation response induced by infection especially bacterial endotoxin translocation, which severely increases mortality in combination with acute colon injury. Bromodomain-containing protein 4 (BRD4) is an important Bromo and Extra-Terminal (BET) protein to participate in...

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Bibliographic Details
Main Authors: Ling Chen, Xiaolin Zhong, Wenyu Cao, Mingli Mao, Wei Li, Hui Yang, Menglin Li, Mengmeng Shi, Yuan Zhang, Yincheng Deng, Xuyu Zu, Jianghua Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
colon injury
BRD4
pyroptosis
JQ1
endotoxemia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.609319/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.609319/full

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