Brefeldin A promotes the appearance of oligosaccharyl phosphates derived from Glc3Man9GlcNAc2-PP-dolichol within the endomembrane system of HepG2 cells

Brefeldin A promotes the appearance of oligosaccharyl phosphates derived from Glc3Man9GlcNAc2-PP-dolichol within the endomembrane system of HepG2 cells

We reported an oligosaccharide diphosphodolichol (DLO) diphosphatase (DLODP) that generates dolichyl-phosphate and oligosaccharyl phosphates (OSPs) from DLO in vitro. This enzyme could underlie cytoplasmic OSP generation and promote dolichyl-phosphate recycling from truncated endoplasmic reticulum (...

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Bibliographic Details
Main Authors: Ahmad Massarweh, Michaël Bosco, Soria Iatmanen-Harbi, Clarice Tessier, Laura Amana, Patricia Busca, Isabelle Chantret, Christine Gravier-Pelletier, Stuart E.H. Moore
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Journal of Lipid Research
Subjects:
ALG12-CDG
endomannosidase
endoplasmic reticulum
Golgi apparatus
glycolipids
isoprenoids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520352196

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http://www.sciencedirect.com/science/article/pii/S0022227520352196

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