The Limonoids TS3 and Rubescin E Induce Apoptosis in Human Hepatoma Cell Lines and Interfere with NF-κB Signaling.

Hepatocellular carcinoma (HCC) is extremely resistant towards pharmacological therapy. To date, the multi-kinase inhibitor Sorafenib is the only available therapeutic agent with the potential to prolong patient survival. Using the human hepatoma cell lines HepG2 and Huh7, we analyzed anti-cancer act...

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Bibliographic Details
Main Authors: Nicole Lange, Armelle Tsamo Tontsa, Claudia Wegscheid, Pierre Mkounga, Augustin Ephrem Nkengfack, Christine Loscher, Gabriele Sass, Gisa Tiegs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4982607?pdf=render