Genetic deletion of Abcc6 disturbs cholesterol homeostasis in mice

Genetic deletion of Abcc6 disturbs cholesterol homeostasis in mice

Abstract Genetic studies link adenosine triphosphate-binding cassette transporter C6 (ABCC6) mutations to pseudoxanthoma elasticum (PXE). ABCC6 sequence variations are correlated with altered HDL cholesterol levels and an elevated risk of coronary artery diseases. However, the role of ABCC6 in chole...

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Bibliographic Details
Main Authors: Bettina Ibold, Janina Tiemann, Isabel Faust, Uta Ceglarek, Julia Dittrich, Theo G. M. F. Gorgels, Arthur A. B. Bergen, Olivier Vanakker, Matthias Van Gils, Cornelius Knabbe, Doris Hendig
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81573-1

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https://doi.org/10.1038/s41598-021-81573-1

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