Combination of Selected MET and EGFR Inhibitors Decreases Melanoma Cells’ Invasive Abilities

Combination of Selected MET and EGFR Inhibitors Decreases Melanoma Cells’ Invasive Abilities

We have previously shown that combination of foretinib, an inhibitor of MET (hepatocyte growth factor receptor), with gefitinib or lapatinib, inhibitors of EGFR (epidermal growth factor receptor), has a synergistic cytotoxic effect on melanoma cells. However, there are cancer cells resistant to drug...

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Bibliographic Details
Main Authors: Aleksandra Simiczyjew, Katarzyna Pietraszek-Gremplewicz, Ewelina Dratkiewicz, Marta Podgórska, Rafał Matkowski, Marcin Ziętek, Dorota Nowak
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
gefitinib
lapatinib
foretinib
melanoma
invasion
invadopodia
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01116/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01116/full

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