Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT1 (AT1a) Receptor/NHE3 Signaling Plays a Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury

Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT1 (AT1a) Receptor/NHE3 Signaling Plays a Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury

Hypertension is well recognized to be the most important risk factor for cardiovascular diseases, stroke, and end-stage kidney failure. A quarter of the world’s adult populations and 46% of the US adults develop hypertension and currently require antihypertensive treatments. Only 50% of hypertensive...

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Bibliographic Details
Main Authors: Xiao Chun Li, Chih-Hong Wang, Ana Paula Oliveira Leite, Jia Long Zhuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
angiotensin II
AT1 receptors/AT2 receptors
hypertension
kidney
proximal tubule
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.702797/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.702797/full

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