Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice.

Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice.

BACKGROUND: Chronic inflammation and oxidative stress play fundamental roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). Previously, we reported that myeloperoxidase (MPO), an aggressive oxidant-generating neutrophil enzyme, is associated with NASH severity in man. We now investigat...

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Bibliographic Details
Main Authors: Sander S Rensen, Veerle Bieghs, Sofia Xanthoulea, Evi Arfianti, Jaap A Bakker, Ronit Shiri-Sverdlov, Marten H Hofker, Jan Willem Greve, Wim A Buurman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3527496?pdf=render

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http://europepmc.org/articles/PMC3527496?pdf=render

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