Understanding Spreading Depression from Headache to Sudden Unexpected Death

Spreading depression (SD) is a neurophysiological phenomenon characterized by abrupt changes in intracellular ion gradients and sustained depolarization of neurons. It leads to loss of electrical activity, changes in the synaptic architecture, and an altered vascular response. Although SD is often d...

Full description

Bibliographic Details
Main Authors: Olga Cozzolino, Maria Marchese, Francesco Trovato, Enrico Pracucci, Gian Michele Ratto, Maria Gabriella Buzzi, Federico Sicca, Filippo M. Santorelli
Format: Article
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Neurology
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2018.00019/full