Characterization of metabolism feature and potential pharmacological changes of morusin-a promising anti-tumor drug-by ultra-high-performance liquid chromatography coupled time-of-flight mass spectrometry and network pharmacology

Characterization of metabolism feature and potential pharmacological changes of morusin-a promising anti-tumor drug-by ultra-high-performance liquid chromatography coupled time-of-flight mass spectrometry and network pharmacology

Morusin, a prenylated flavone isolated from Morus species, was treated as a potential anti-tumor drug since it inhibited effects on numerous types of human cancer cells. In some sense, drugs-related metabolites always contribute to pharmacological changes, inducing therapy improvement, reduced effic...

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Bibliographic Details
Main Authors: Feng-xiang Zhang, Yu-lin-lan Yuan, Jing-yun Wang, Zi-ting Li, Shuang-shuang Cui, Feng-cheng Zhu, Di Qiu, Yun Wang, Rui-man Li
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Arabian Journal of Chemistry
Subjects:
Morusin
Metabolism feature
Network pharmacology
UHPLC-Q/TOF MS
Pharmacological changes
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535220305256

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http://www.sciencedirect.com/science/article/pii/S1878535220305256

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