Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis

Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis

Abstract Background Inactivation of the tumor suppressor p53 is critical for pathogenesis of glioma, in particular glioblastoma multiforme (GBM). MDM2, the main negative regulator of p53, binds to and forms a stable complex with p53 to regulate its activity. Hitherto, it is unclear whether the stabi...

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Bibliographic Details
Main Authors: Jiacheng Lou, Yuchao Hao, Kefeng Lin, Yizhu Lyu, Meiwei Chen, Han Wang, Deyu Zou, Xuewen Jiang, Renchun Wang, Di Jin, Eric W.-F. Lam, Shujuan Shao, Quentin Liu, Jinsong Yan, Xiang Wang, Puxiang Chen, Bo Zhang, Bilian Jin
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Molecular Cancer
Subjects:
CDR1as
p53
MDM2
DNA damage
Glioma
Online Access:http://link.springer.com/article/10.1186/s12943-020-01253-y

Internet

http://link.springer.com/article/10.1186/s12943-020-01253-y

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