Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis

<p>Abstract</p> <p>Background</p> <p>Pancreatic ductal adenocarcinoma shows a distinct apoptosis resistance, which contributes significantly to the aggressive nature of this tumor and constrains the effectiveness of new therapeutic strategies. Apoptosis resistance is de...

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Bibliographic Details
Main Authors: Grützmann Robert, Saeger Hans-Detlev, Lehner Anne-Kathrin, Samm Nicole, Rückert Felix, Pilarsky Christian
Format: Article
Language:English
Published: BMC 2010-07-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/10/379