Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

Somatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.

Bibliographic Details
Main Authors: Kimiko Inoue, Narumi Ogonuki, Satoshi Kamimura, Hiroki Inoue, Shogo Matoba, Michiko Hirose, Arata Honda, Kento Miura, Masashi Hada, Ayumi Hasegawa, Naomi Watanabe, Yukiko Dodo, Keiji Mochida, Atsuo Ogura
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16044-8

Internet

https://doi.org/10.1038/s41467-020-16044-8

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