Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

Somatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.

Bibliographic Details
Main Authors: Kimiko Inoue, Narumi Ogonuki, Satoshi Kamimura, Hiroki Inoue, Shogo Matoba, Michiko Hirose, Arata Honda, Kento Miura, Masashi Hada, Ayumi Hasegawa, Naomi Watanabe, Yukiko Dodo, Keiji Mochida, Atsuo Ogura
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16044-8
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spelling doaj-9a90abcae67c4e6d8be26b81b3d9af932021-05-11T08:52:36ZengNature Publishing GroupNature Communications2041-17232020-05-0111111210.1038/s41467-020-16044-8Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentasKimiko Inoue0Narumi Ogonuki1Satoshi Kamimura2Hiroki Inoue3Shogo Matoba4Michiko Hirose5Arata Honda6Kento Miura7Masashi Hada8Ayumi Hasegawa9Naomi Watanabe10Yukiko Dodo11Keiji Mochida12Atsuo Ogura13Bioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENBioresource Engineering Division, Bioresource Research Center, RIKENSomatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.https://doi.org/10.1038/s41467-020-16044-8
collection DOAJ
language English
format Article
sources DOAJ
author Kimiko Inoue
Narumi Ogonuki
Satoshi Kamimura
Hiroki Inoue
Shogo Matoba
Michiko Hirose
Arata Honda
Kento Miura
Masashi Hada
Ayumi Hasegawa
Naomi Watanabe
Yukiko Dodo
Keiji Mochida
Atsuo Ogura
spellingShingle Kimiko Inoue
Narumi Ogonuki
Satoshi Kamimura
Hiroki Inoue
Shogo Matoba
Michiko Hirose
Arata Honda
Kento Miura
Masashi Hada
Ayumi Hasegawa
Naomi Watanabe
Yukiko Dodo
Keiji Mochida
Atsuo Ogura
Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
Nature Communications
author_facet Kimiko Inoue
Narumi Ogonuki
Satoshi Kamimura
Hiroki Inoue
Shogo Matoba
Michiko Hirose
Arata Honda
Kento Miura
Masashi Hada
Ayumi Hasegawa
Naomi Watanabe
Yukiko Dodo
Keiji Mochida
Atsuo Ogura
author_sort Kimiko Inoue
title Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
title_short Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
title_full Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
title_fullStr Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
title_full_unstemmed Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas
title_sort loss of h3k27me3 imprinting in the sfmbt2 mirna cluster causes enlargement of cloned mouse placentas
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-05-01
description Somatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.
url https://doi.org/10.1038/s41467-020-16044-8
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