hnRNPH2 as an Inhibitor of Chicken MDA5-Mediated Type I Interferon Response: Analysis Using Chicken MDA5–Host Interactome

hnRNPH2 as an Inhibitor of Chicken MDA5-Mediated Type I Interferon Response: Analysis Using Chicken MDA5–Host Interactome

RIG-I and MDA5 are two key pattern recognition receptors that sense the invasion of RNA viruses and initiate type I interferon (IFN) response. Although these receptors are generally conserved in vertebrates, RIG-I is absent in chickens, whereas MDA5 is present. Chicken MDA5 (chMDA5) plays a pivotal...

Full description

Bibliographic Details
Main Authors: Xian Lin, Shiman Yu, Haiying Mao, Peilei Ren, Meilin Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
chicken MDA5
interactome
chicken IFN-β
HNRNPH2
immune regulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.541267/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.541267/full

Similar Items