Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection

Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection

Abstract Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansion, important in the acute response in the lung; (2) as DC modulators, limiting the...

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Bibliographic Details
Main Authors: Adam Brufsky, Juan Luis Gomez Marti, Azadeh Nasrazadani, Michael T. Lotze
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Translational Medicine
Subjects:
SARS Coronavirus
Immune response
Glycoproteins
Bisphosphonates
Online Access:http://link.springer.com/article/10.1186/s12967-020-02433-6

Internet

http://link.springer.com/article/10.1186/s12967-020-02433-6

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