Correlation of β-Catenin Localization with Cyclooxygenase-2 Expression and CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer

Correlation of β-Catenin Localization with Cyclooxygenase-2 Expression and CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer

The WNT/β-catenin (CTNNB1) pathway is commonly activated in the carcinogenic process. Cross-talks between the WNT and cyclooxygenase-2 (COX-2 or PTGS2)/prostaglandin pathways have been suggested. The relationship between (3-catenin activation and microsatellite instability (MSI) in colorectal cance...

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Bibliographic Details
Main Authors: Takako Kawasaki, Katsuhiko Nosho, Mutsuko Ohnishi, Yuko Suemoto, Gregory J. Kirkner, Reiko Dehari, Jeffrey A. Meyerhardt, Charles S. Fuchs, Shuji Ogino
Format: Article
Language:English
Published: Elsevier 2007-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Colon cancer
CTNNBI
CpG island methylator phenotype
PTGS2
microsatellite instability
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800820

Internet

http://www.sciencedirect.com/science/article/pii/S1476558607800820

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