Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways

Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways

<p><b>Abstract</b></p> <p><b>Background</b></p> <p>Blockade of angiotensin II type 1 (AT<sub>1</sub>) receptors ameliorates brain inflammation, and reduces excessive brain interleukin-1 beta (IL-1β) production and release from cortica...

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Bibliographic Details
Main Authors: Pang Tao, Wang Juan, Benicky Julius, Sánchez-Lemus Enrique, Saavedra Juan M
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Journal of Neuroinflammation
Subjects:
Angiotensin II AT<sub>1</sub> receptor blockers
SK-N-SH neuroblasts
Cortical neurons
Neuronal inflammation
Neuroprotection
Oxidative stress
COX-2
PGE<sub>2</sub> release
JNK activation
IL-1β neurotoxicity
Online Access:http://www.jneuroinflammation.com/content/9/1/102

Internet

http://www.jneuroinflammation.com/content/9/1/102

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