Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry

Summary: Store-operated calcium entry (SOCE) through STIM-gated ORAI channels governs vital cellular functions. In this context, SOCE controls cellular redox signaling and is itself regulated by redox modifications. However, the molecular mechanisms underlying this calcium-redox interplay and the fu...

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Bibliographic Details
Main Authors: Christine Silvia Gibhardt, Sabrina Cappello, Rajesh Bhardwaj, Romana Schober, Sonja Agnes Kirsch, Zuriñe Bonilla del Rio, Stefan Gahbauer, Anna Bochicchio, Magdalena Sumanska, Christian Ickes, Ioana Stejerean-Todoran, Miso Mitkovski, Dalia Alansary, Xin Zhang, Aram Revazian, Marc Fahrner, Victoria Lunz, Irene Frischauf, Ting Luo, Daria Ezerina, Joris Messens, Vsevolod Vadimovich Belousov, Markus Hoth, Rainer Arnold Böckmann, Matthias Albrecht Hediger, Rainer Schindl, Ivan Bogeski
Format: Article
Published: Elsevier 2020-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031281X