Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2

Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2

Abstract Hypoxia is a common feature of solid tumours that promotes invasion and metastatic dissemination. Invadopodia are actin-rich membrane protrusions that direct extracellular matrix proteolysis and facilitate tumour cell invasion. Here, we show that CSRP2, an invadopodial actin bundling protei...

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Bibliographic Details
Main Authors: Céline Hoffmann, Xianqing Mao, Joshua Brown-Clay, Flora Moreau, Antoun Al Absi, Hannah Wurzer, Barbara Sousa, Fernando Schmitt, Guy Berchem, Bassam Janji, Clément Thomas
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-28637-x

Internet

https://doi.org/10.1038/s41598-018-28637-x

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