Reduction of the Nitro Group to Amine by Hydroiodic Acid to Synthesize o-Aminophenol Derivatives as Putative Degradative Markers of Neuromelanin

Reduction of the Nitro Group to Amine by Hydroiodic Acid to Synthesize o-Aminophenol Derivatives as Putative Degradative Markers of Neuromelanin

Neuromelanin (NM) is produced in dopaminergic neurons of the substantia nigra (SN) and in noradrenergic neurons of the locus coeruleus (LC). The synthesis of NM in those neurons is a component of brain aging and there is the evidence that this pigment can be involved in the pathogenesis of neurodeg...

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Bibliographic Details
Main Authors: Kazumasa Wakamatsu, Hitomi Tanaka, Keisuke Tabuchi, Makoto Ojika, Fabio A. Zucca, Luigi Zecca, Shosuke Ito
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Molecules
Subjects:
neuromelanin
aminohydroxyphenylethylamine
aminohydroxyphenylacetic acid
aminohydroxyethylbenzene
Parkinson’s disease
HI reduction
Online Access:http://www.mdpi.com/1420-3049/19/6/8039

Internet

http://www.mdpi.com/1420-3049/19/6/8039

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