Critical role of miR-10b in B-RafV600E dependent anchorage independent growth and invasion of melanoma cells.

Critical role of miR-10b in B-RafV600E dependent anchorage independent growth and invasion of melanoma cells.

Recent high-throughput-sequencing of cancer genomes has identified oncogenic mutations in the B-Raf genetic locus as one of the critical events in melanomagenesis. B-Raf encodes a serine/threonine kinase that regulates the MAPK/ERK kinase (MEK) and extracellular signal-regulated kinase (ERK) protein...

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Bibliographic Details
Main Authors: Ila Datar, Gardiyawasam Kalpana, Jungmin Choi, Tupa Basuroy, Robert Trumbly, Sri Krishna Chaitanya Arudra, Michael D McPhee, Ivana de la Serna, Kam C Yeung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0204387

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https://doi.org/10.1371/journal.pone.0204387

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