14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling

14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling

Abstract Background 14,15-epoxyeicosatrienoic acid (14,15-EET) is an important lipid signaling molecule involved in the regulation of tumor metastasis, however, the role and molecular mechanisms of 14,15-EET activity in breast cancer cell epithelial-mesenchymal transition (EMT) and drug resistance r...

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Bibliographic Details
Main Authors: Jing Luo, Jian-Feng Yao, Xiao-Fei Deng, Xiao-Dan Zheng, Min Jia, Yue-Qin Wang, Yan Huang, Jian-Hua Zhu
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
14, 15-EET
EMT
Cisplatin resistance
αvβ3/FAK/PI3K/AKT signaling
Online Access:http://link.springer.com/article/10.1186/s13046-018-0694-6

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http://link.springer.com/article/10.1186/s13046-018-0694-6

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