ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis

ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis

Abstract Background Diabetic nephropathy (DN) contributes to end-stage renal failure. Microvascular injury resulted from reactive oxygen species is implicated in the pathogenesis of DN. Genetic polymorphism of Apolipoprotein E (APOE) influences the antioxidative properties of the protein. The relati...

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Bibliographic Details
Main Authors: Jikang Shi, Zhaorui Cheng, Shuang Qiu, Heran Cui, Yulu Gu, Qian Zhao, Yaxuan Ren, He Zhang, Helin Sun, Yunkai Liu, Yong Li, Yichun Qiao, Yueyang Hu, Yawen Liu, Yi Cheng
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Lipids in Health and Disease
Subjects:
Diabetic nephropathy
Type 2 diabetes
Apolipoprotein E
Polymorphism
Risk
Association
Online Access:http://link.springer.com/article/10.1186/s12944-020-01307-6

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http://link.springer.com/article/10.1186/s12944-020-01307-6

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