Induction of cell death in ovarian cancer cells by doxorubicin and oncolytic vaccinia virus is associated with CREB3L1 activation

Induction of cell death in ovarian cancer cells by doxorubicin and oncolytic vaccinia virus is associated with CREB3L1 activation

We have demonstrated that oncolytic vaccinia virus synergizes with doxorubicin (DOX) in inducing immunogenic cell death in platinum-resistant ovarian cancer cells and increases survival in syngeneic and xenograft tumor models. However, the mechanisms underlying the virus- and doxorubicin-mediated ca...

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Bibliographic Details
Main Authors: Anna Mistarz, Matthew Graczyk, Marta Winkler, Prashant K. Singh, Eduardo Cortes, Anthony Miliotto, Song Liu, Mark Long, Li Yan, Aimee Stablewski, Kieran O’Loughlin, Hans Minderman, Kunle Odunsi, Hanna Rokita, A.J. Robert McGray, Emese Zsiros, Danuta Kozbor
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
doxorubicin
CREB3L1
oncolytic vaccinia virus
ovarian cancer
IFN-β
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000644

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http://www.sciencedirect.com/science/article/pii/S2372770521000644

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