The Immunomodulator 1-Methyltryptophan Drives Tryptophan Catabolism Toward the Kynurenic Acid Branch

The Immunomodulator 1-Methyltryptophan Drives Tryptophan Catabolism Toward the Kynurenic Acid Branch

Background: Animal model studies revealed that the application of 1-methyltryptophan (1-MT), a tryptophan (TRP) analog, surprisingly increased plasma levels of the TRP metabolite, kynurenic acid (KYNA). Under inflammatory conditions, KYNA has been shown to mediate various immunomodulatory effects. T...

Full description

Bibliographic Details
Main Authors: Elisa Wirthgen, Anne K. Leonard, Christian Scharf, Grazyna Domanska
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
1-MT
IDO
KYNA
kynurenine pathway
tryptophan
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00313/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00313/full

Similar Items