Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: the VIVE2 randomized controlled trial
Abstract Background Health-related quality of life (HRQoL) and absence of depressive symptoms are of great importance for older people, which may be achieved through lifestyle interventions, e.g., exercise and nutrition interventions. The aim of this investigation was to analyze the effects of a phy...
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doaj-9acc09af2c19414bbf4339719ef405d52020-11-25T03:38:18ZengBMCBMC Geriatrics1471-23182018-11-011811810.1186/s12877-018-0976-zEffect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: the VIVE2 randomized controlled trialÅsa von Berens0Roger A. Fielding1Thomas Gustafsson2Dylan Kirn3Jonathan Laussen4Margaretha Nydahl5Kieran Reid6Thomas G. Travison7Hao Zhu8Tommy Cederholm9Afsaneh Koochek10Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala UniversityNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts UniversityDepartment of Laboratory Medicine, Karolinska InstituteNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts UniversityNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts UniversityDepartment of Food studies, Nutrition and Dietetics, Uppsala UniversityNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts UniversityHarvard Medical SchoolInstitute for Aging Research, Hebrew SeniorLifeDepartment of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala UniversityDepartment of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala UniversityAbstract Background Health-related quality of life (HRQoL) and absence of depressive symptoms are of great importance for older people, which may be achieved through lifestyle interventions, e.g., exercise and nutrition interventions. The aim of this investigation was to analyze the effects of a physical activity program in combination with protein supplementation on HRQoL and depressive symptoms in community-dwelling, mobility-limited older adults. Methods In the Vitality, Independence, and Vigor 2 Study (VIVE2), community-dwelling men and women with an average age of 77.5 ± 5.4 years, some mobility limitations and low serum vitamin D levels (25(OH)Vit D 22.5–60 nmol/l) from two study sites (Stockholm, Sweden and Boston, USA) were randomized to receive a nutritional supplement or a placebo for 6 months. All took part in a physical activity program 2–3 times/ week. The primary outcome examined in VIVE2 was 400 M walk capacity. HRQoL was measured using the Medical Outcomes Study 36-item Short Form Health Survey (SF36), consisting of the Physical Component Summary (PCS) and Mental Component Summary (MCS), and depressive symptoms were measured using The Centre for Epidemiologic Studies Depression Scale (CES-D). In the sensitivity analyses, the sample was divided into sub-groups based on body measures and function (body mass index (BMI), appendicular lean mass index (ALMI), handgrip strength and gait speed). Results For the whole sample, there was a significant improvement in both MCS, mean (95% CI) 2.68 (0.5, 4.9) (p 0.02), and CES-D -2.7 (− 4.5, − 0.9) (p 0.003) during the intervention, but no difference was detected between those who received the nutritional supplement and those who received the placebo. The results revealed no significant change in PCS or variation in effects across the sub-categories. Conclusions This study demonstrates that a six-month intervention using a physical activity program had positive effects on mental status. No additional effects from nutritional supplementation were detected. Trial registration Registered at ClinicalTrials.gov, March 2 2012, NCT01542892.http://link.springer.com/article/10.1186/s12877-018-0976-zPhysical activityNutritional supplementationHealth-related quality of lifeDepressive symptoms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Åsa von Berens Roger A. Fielding Thomas Gustafsson Dylan Kirn Jonathan Laussen Margaretha Nydahl Kieran Reid Thomas G. Travison Hao Zhu Tommy Cederholm Afsaneh Koochek |
spellingShingle |
Åsa von Berens Roger A. Fielding Thomas Gustafsson Dylan Kirn Jonathan Laussen Margaretha Nydahl Kieran Reid Thomas G. Travison Hao Zhu Tommy Cederholm Afsaneh Koochek Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: the VIVE2 randomized controlled trial BMC Geriatrics Physical activity Nutritional supplementation Health-related quality of life Depressive symptoms |
author_facet |
Åsa von Berens Roger A. Fielding Thomas Gustafsson Dylan Kirn Jonathan Laussen Margaretha Nydahl Kieran Reid Thomas G. Travison Hao Zhu Tommy Cederholm Afsaneh Koochek |
author_sort |
Åsa von Berens |
title |
Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: the VIVE2 randomized controlled trial |
title_short |
Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: the VIVE2 randomized controlled trial |
title_full |
Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: the VIVE2 randomized controlled trial |
title_fullStr |
Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: the VIVE2 randomized controlled trial |
title_full_unstemmed |
Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: the VIVE2 randomized controlled trial |
title_sort |
effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: the vive2 randomized controlled trial |
publisher |
BMC |
series |
BMC Geriatrics |
issn |
1471-2318 |
publishDate |
2018-11-01 |
description |
Abstract Background Health-related quality of life (HRQoL) and absence of depressive symptoms are of great importance for older people, which may be achieved through lifestyle interventions, e.g., exercise and nutrition interventions. The aim of this investigation was to analyze the effects of a physical activity program in combination with protein supplementation on HRQoL and depressive symptoms in community-dwelling, mobility-limited older adults. Methods In the Vitality, Independence, and Vigor 2 Study (VIVE2), community-dwelling men and women with an average age of 77.5 ± 5.4 years, some mobility limitations and low serum vitamin D levels (25(OH)Vit D 22.5–60 nmol/l) from two study sites (Stockholm, Sweden and Boston, USA) were randomized to receive a nutritional supplement or a placebo for 6 months. All took part in a physical activity program 2–3 times/ week. The primary outcome examined in VIVE2 was 400 M walk capacity. HRQoL was measured using the Medical Outcomes Study 36-item Short Form Health Survey (SF36), consisting of the Physical Component Summary (PCS) and Mental Component Summary (MCS), and depressive symptoms were measured using The Centre for Epidemiologic Studies Depression Scale (CES-D). In the sensitivity analyses, the sample was divided into sub-groups based on body measures and function (body mass index (BMI), appendicular lean mass index (ALMI), handgrip strength and gait speed). Results For the whole sample, there was a significant improvement in both MCS, mean (95% CI) 2.68 (0.5, 4.9) (p 0.02), and CES-D -2.7 (− 4.5, − 0.9) (p 0.003) during the intervention, but no difference was detected between those who received the nutritional supplement and those who received the placebo. The results revealed no significant change in PCS or variation in effects across the sub-categories. Conclusions This study demonstrates that a six-month intervention using a physical activity program had positive effects on mental status. No additional effects from nutritional supplementation were detected. Trial registration Registered at ClinicalTrials.gov, March 2 2012, NCT01542892. |
topic |
Physical activity Nutritional supplementation Health-related quality of life Depressive symptoms |
url |
http://link.springer.com/article/10.1186/s12877-018-0976-z |
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