Quantitative model of cell cycle arrest and cellular senescence in primary human fibroblasts.

Quantitative model of cell cycle arrest and cellular senescence in primary human fibroblasts.

Primary human fibroblasts in tissue culture undergo a limited number of cell divisions before entering a non-replicative "senescent" state. At early population doublings (PD), fibroblasts are proliferation-competent displaying exponential growth. During further cell passaging, an increasin...

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Bibliographic Details
Main Authors: Sascha Schäuble, Karolin Klement, Shiva Marthandan, Sandra Münch, Ines Heiland, Stefan Schuster, Peter Hemmerich, Stephan Diekmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3413708?pdf=render

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http://europepmc.org/articles/PMC3413708?pdf=render

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