Endothelial progenitor cells-derived exosomal microRNA-21-5p alleviates sepsis-induced acute kidney injury by inhibiting RUNX1 expression

Abstract The role of microRNA-21-5p (miR-21-5p) in sepsis-induced acute kidney injury (AKI) has been seldom discussed. Therefore, the objective of this present study was to investigate the mechanism of endothelial progenitor cells-derived exosomes (EPCs-exos) in sepsis-induced AKI via miR-21-5p/runt...

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Bibliographic Details
Main Authors: Yue Zhang, Hongdong Huang, Wenhu Liu, Sha Liu, Xue Yan Wang, Zong Li Diao, Ai Hua Zhang, Wang Guo, Xue Han, Xiaoqun Dong, Oleksandr Katilov
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03578-y