In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST4 Receptor Agonists

In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST4 Receptor Agonists

Background: Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via its receptor subtype 4 (SST4) without influencing endocrine functions. Therefore, SST4 is considered to be a novel target for drug development in pain, especially chroni...

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Main Authors: Boglárka Kántás, Éva Szőke, Rita Börzsei, Péter Bánhegyi, Junaid Asghar, Lina Hudhud, Anita Steib, Ágnes Hunyady, Ádám Horváth, Angéla Kecskés, Éva Borbély, Csaba Hetényi, Gábor Pethő, Erika Pintér, Zsuzsanna Helyes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
neuropathic pain
drug discovery
G protein coupled receptor
somatostatin
somatostatin receptor subtype 4
molecular
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.601887/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.601887/full

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