IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal

IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal

Chronic hepatitis leads to liver fibrosis and cirrhosis. Cirrhosis is a major cause of worldwide morbidity and mortality. Macrophages play a key role in fibrosis progression and reversal. However, the signals that determine fibrogenic vs fibrolytic macrophage function remain ill defined. We studied...

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Bibliographic Details
Main Authors: Shih-Yen Weng, Xiaoyu Wang, Santosh Vijayan, Yilang Tang, Yong Ook Kim, Kornelius Padberg, Tommy Regen, Olena Molokanova, Tao Chen, Tobias Bopp, Hansjörg Schild, Frank Brombacher, Jeff R. Crosby, Michael L. McCaleb, Ari Waisman, Ernesto Bockamp, Detlef Schuppan
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641830032X

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http://www.sciencedirect.com/science/article/pii/S235239641830032X

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