Melatonin Ameliorates The Production of COX-2, iNOS, and The Formation of 8-OHdG in Non-Targeted Lung Tissue after Pelvic Irradiation

Melatonin Ameliorates The Production of COX-2, iNOS, and The Formation of 8-OHdG in Non-Targeted Lung Tissue after Pelvic Irradiation

In this study, we evaluated the bystander effect of radiation on the regulation of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and 8-hydroxydeoxyguanosine (8-OHdG) in lung tissues of Sprague-Dawley rats with and without pre-administration of melatonin. A 2×2 cm2 area of the pel...

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Bibliographic Details
Main Authors: Reza Fardid, Ashkan Salajegheh, Mohammad Amin Mosleh-Shirazi, Sedigheh Sharifzadeh, Mohammad Ali Okhovat, Masoud Najafi, Abolhasan Rezaeiyan, Akbar Abaszadeh
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2017-04-01
Series:Cell Journal
Subjects:
Radiation-Induced Bystander Effect
Melatonin
Cyclooxygenase-2
Inducible Nitric Oxide Synthase
8-Hydroxydeoxyguanosine
Online Access:http://celljournal.org/journal/article/10435/download

Internet

http://celljournal.org/journal/article/10435/download

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