Improvement of Morphine-Mediated Analgesia by Inhibition of β-Arrestin 2 Expression in Mice Periaqueductal Gray Matter

Improvement of Morphine-Mediated Analgesia by Inhibition of β-Arrestin 2 Expression in Mice Periaqueductal Gray Matter

Morphine is a well-known μ-opioid receptor (MOR) agonist and an efficient analgesic, but its long-term use inevitably leads to drug addiction and tolerance. Here, we show that specific inhibition of β-arrestin2 with its siRNA lentivirus microinjected in mice periaqueductal gray matter (PAG) signific...

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Bibliographic Details
Main Authors: Yuting Li, Xing Liu, Chang Liu, Jiuhong Kang, Jingyu Yang, Gang Pei, Chunfu Wu
Format: Article
Language:English
Published: MDPI AG 2009-03-01
Series:International Journal of Molecular Sciences
Subjects:
β-Arrestin 2
Lentivirus
Periaqueductal gray
Analgesia
Morphine
Online Access:http://www.mdpi.com/1422-0067/10/3/954/

Internet

http://www.mdpi.com/1422-0067/10/3/954/

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