Intrathecal B Cells in MS Have Significantly Greater Lymphangiogenic Potential Compared to B Cells Derived From Non-MS Subjects

Intrathecal B Cells in MS Have Significantly Greater Lymphangiogenic Potential Compared to B Cells Derived From Non-MS Subjects

Although B cell depletion is an effective therapy of multiple sclerosis (MS), the pathogenic functions of B cells in MS remain incompletely understood. We asked whether cerebrospinal fluid (CSF) B cells in MS secrete different cytokines than control-subject B cells and whether cytokine secretion aff...

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Bibliographic Details
Main Authors: Jason Stein, Quangang Xu, Kayla C. Jackson, Elena Romm, Simone C. Wuest, Peter Kosa, Tianxia Wu, Bibiana Bielekova
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Neurology
Subjects:
lymphangiogenesis
B cell immunology
multiple sclerosis
intrathecal inflammation
tertiary lymphoid follicles
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00554/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00554/full

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