Improving the Thermostability and Activity of Transaminase From Aspergillus terreus by Charge-Charge Interaction

Improving the Thermostability and Activity of Transaminase From Aspergillus terreus by Charge-Charge Interaction

Transaminases that promote the amination of ketones into amines are an emerging class of biocatalysts for preparing a series of drugs and their intermediates. One of the main limitations of (R)-selective amine transaminase from Aspergillus terreus (At-ATA) is its weak thermostability, with a half-li...

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Bibliographic Details
Main Authors: Jia-Ren Cao, Fang-Fang Fan, Chang-Jiang Lv, Hong-Peng Wang, Ye Li, Sheng Hu, Wei-Rui Zhao, Hai-Bin Chen, Jun Huang, Le-He Mei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Chemistry
Subjects:
amine transaminase
thermostability
enzyme thermal stability system
site-directed mutagenesis
molecular dynamics simulations
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.664156/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.664156/full

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