Transcriptomic and proteomic intra-tumor heterogeneity of colorectal cancer varies depending on tumor location within the colorectum.

Transcriptomic and proteomic intra-tumor heterogeneity of colorectal cancer varies depending on tumor location within the colorectum.

<h4>Background</h4>Intra-tumor heterogeneity (ITH) of colorectal cancer (CRC) complicates molecular tumor classification, such as transcriptional subtyping. Differences in cellular states, biopsy cell composition, and tumor microenvironment may all lead to ITH. Here we analyze ITH at the...

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Bibliographic Details
Main Authors: Sigrid Salling Árnadóttir, Trine Block Mattesen, Søren Vang, Mogens Rørbæk Madsen, Anders Husted Madsen, Nicolai Juul Birkbak, Jesper Bertram Bramsen, Claus Lindbjerg Andersen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0241148

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https://doi.org/10.1371/journal.pone.0241148

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