Phosphoinositide 3-Kinase p110 Delta Differentially Restrains and Directs Naïve Versus Effector CD8+ T Cell Transcriptional Programs

Phosphoinositide 3-Kinase p110 Delta Differentially Restrains and Directs Naïve Versus Effector CD8+ T Cell Transcriptional Programs

Phosphoinositide 3-kinase p110 delta (PI3K p110δ) is pivotal for CD8+ T cell immune responses. The current study explores PI3K p110δ induction and repression of antigen receptor and cytokine regulated programs to inform how PI3K p110δ directs CD8+ T cell fate. The studies force a revision of the con...

Full description

Bibliographic Details
Main Authors: Laura Spinelli, Julia M. Marchingo, Aneela Nomura, Marcos P. Damasio, Doreen A. Cantrell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
PI3K
p110δ
CD8+ T cells
TCR signalling
transcriptomics
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.691997/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.691997/full

Similar Items