Mechanisms Underlying Activation of α1-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions

Mechanisms Underlying Activation of α1-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions

Defective cellular trafficking of aquaporin-5 (AQP5) to the apical plasma membrane (APM) in salivary glands is associated with the loss of salivary fluid secretion. To examine mechanisms of α1-adrenoceptor (AR)-induced trafficking of AQP5, immunoconfocal microscopy and Western blot analysis were use...

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Bibliographic Details
Main Authors: Aneta M. Bragiel, Di Wang, Tomasz D. Pieczonka, Masayuki Shono, Yasuko Ishikawa
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
aquaporin-5
α1A-adrenoceptor
α1B-adrenoceptor
α1D-adrenoceptor
calcium
protein G kinase
hypotonicity
Online Access:http://www.mdpi.com/1422-0067/17/7/1022

Internet

http://www.mdpi.com/1422-0067/17/7/1022

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