The Dual Role of Microglia in ALS: Mechanisms and Therapeutic Approaches

The Dual Role of Microglia in ALS: Mechanisms and Therapeutic Approaches

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a non-cell autonomous motor neuron loss. While it is generally believed that the disease onset takes place inside motor neurons, different cell types mediating neuroinflammatory processes are considered deeply involv...

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Bibliographic Details
Main Authors: Maria Concetta Geloso, Valentina Corvino, Elisa Marchese, Alessia Serrano, Fabrizio Michetti, Nadia D’Ambrosi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
amyotrophic lateral sclerosis
M1/M2 microglia
neuroinflammation
anti-inflammatory drugs
genetic modifiers
mutant SOD1 mice
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00242/full

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http://journal.frontiersin.org/article/10.3389/fnagi.2017.00242/full

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